Technological Innovation Accelerating Modern Drug Development
Pioneering next-generation solutions for mitochondrial therapeutic development.
The Mitochondria
Mitochondria are the engines of human biology. Beyond producing the energy that powers every cell, they play essential roles in metabolism, cellular signalling, immune function, and the regulation of cell survival. When mitochondrial function is disrupted, the consequences extend across multiple organ systems and are implicated in a growing number of diseases.
Advancing Discovery
Despite their central role in human physiology, the development of mitochondrial therapeutics remains one of the most complex challenges in biomedical research. Progress requires innovative approaches that can overcome longstanding scientific and technical barriers while enabling deeper insights into mitochondrial biology and disease.
About Us
We are advancing the field through technological innovation. We develop next-generation platforms and enabling technologies that accelerate mitochondrial therapeutic discovery and development. By combining cutting-edge science with engineering and translational expertise, we empower researchers and drug developers to better understand mitochondrial function, identify novel therapeutic opportunities, and bring transformative medicines closer to patients.
Our Technologies Driving Discovery
Next-generation platforms that enable smarter drug discovery, deeper biological insight, and earlier prediction of mitochondrial toxicity.
Reddan, B., Shahen, R., Radi, R., McCalmont, M., Green, O. and Cummins, E.P., 2026. Activity-based CO2 sensing using CarboSenR2 provides new insights into cellular metabolism. Redox Biology, p.104067.
Green, O., Finkelstein, P., Rivero-Crespo, M.A., Lutz, M.D., Bogdos, M.K., Burger, M., Leroux, J.C. and Morandi, B., 2022. Activity-based approach for selective molecular CO2 sensing. Journal of the American Chemical Society, 144(19), pp.8717-8724.
Partner With Us
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We work collaboratively with biotechnology, pharmaceutical, and academic partners to accelerate therapeutic discovery through innovative mitochondrial technologies. Whether you require a bespoke assay, access to our proprietary platforms, or a strategic development partner, we provide flexible solutions tailored to your research objectives.
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Collaborative scientific partnerships focused on solving complex biological challenges, advancing therapeutic discovery, and generating high-value translational data.
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Bespoke screening and profiling projects powered by integrated high-throughput, high-content imaging, in vitro, cell-based, and high-content flow cytometry platforms. We provide end-to-end assessment of compound activity, mitochondrial function, cellular phenotypes, and safety, generating multidimensional datasets to support hit discovery, lead optimisation, and mechanistic studies.
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Our proprietary screening technologies are engineered for high-sensitivity detection of mitochondrial loss of function, enabling earlier and more comprehensive identification of mitochondrial liabilities. This provides actionable insights into compound effects on mitochondrial biology and supports confident progression of promising candidates.
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Leverage our proprietary screening technologies, original biological data platforms, and assay datasets to enhance your internal drug discovery capabilities. We offer flexible models for technology access, data integration, and assay deployment, enabling seamless incorporation of our capabilities into existing discovery and development workflows.
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From target identification and validation to HTS, hit discovery, lead optimisation and candidate evaluation, we design and execute bespoke discovery projects across the full spectrum of in vitro and in cellulo biology. Our multimodal approach integrates primary and disease-relevant models, phenotypic and mechanistic assays, advanced screening technologies, and toxicity profiling to deliver comprehensive, decision-ready datasets tailored to each project.
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Our integrated technology platforms support every stage of therapeutic discovery, from early target validation and compound screening to functional characterisation and safety assessment. We combine advanced screening technologies with deep expertise in mitochondrial biology to deliver high-quality, actionable data.
Our Capabilities Include
Flow Cytometry – High-parameter cellular analysis and phenotypic profiling.
In Vitro Screening – Enzyme activity, substrate conversion, inhibitor identification, and potency assessment.
High-Throughput Screening – Scalable screening for large compound libraries and lead identification.
In Cellulo Therapeutic Profiling – Functional assessment of therapeutic candidates in physiologically relevant cellular models.
Mitochondrial Function & Metabolic Profiling – Comprehensive analysis of mitochondrial health, cellular bioenergetics, and metabolic activity.
Mitochondrial Toxicity Screening – Early detection and characterisation of mitochondrial liabilities to improve candidate selection.
High-Content Imaging – Multiparametric imaging to quantify cellular phenotypes, organelle dynamics, and drug responses.
Mechanism of Action Studies – Functional assays to investigate target engagement and biological response.
In Vitro & In Cellulo Assays – Flexible assay formats spanning biochemical, cellular, and translational applications.
Data Analysis & Scientific Interpretation – Comprehensive reporting with expert biological insight to support confident decision-making.
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Innovative proprietary screening technologies
Expertise in mitochondrial biology and therapeutic development
Flexible collaboration and licensing models
Rapid assay development and implementation
Actionable data to support confident decision-making
Dedicated scientific support throughout every stage of your project
Get in Touch
Whether you have a question, an idea, or just want to say hello, feel free to reach out—we’re here to help.